Using phage display to select antibodies recognizing post-translational modifications independently of sequence context.

@article{Kehoe2006UsingPD,
  title={Using phage display to select antibodies recognizing post-translational modifications independently of sequence context.},
  author={John W Kehoe and Nileena Velappan and Monica Walbolt and Jytte Rasmussen and Dave King and Jianlong Lou and Kristeene A. Knopp and Peter Pavlik and James D Marks and Carolyn R Bertozzi and Andrew R. M. Bradbury},
  journal={Molecular & cellular proteomics : MCP},
  year={2006},
  volume={5 12},
  pages={2350-63}
}
Many cellular activities are controlled by post-translational modifications, the study of which is hampered by the lack of specific reagents due in large part to their ubiquitous and non-immunogenic nature. Although antibodies against specifically modified sequences are relatively easy to obtain, it is extremely difficult to derive reagents recognizing post-translational modifications independently of the sequence context surrounding the modification. In this study, we examined the possibility… CONTINUE READING

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