Using penalised logistic regression to fine map HLA variants for rheumatoid arthritis.

Abstract

Rheumatoid arthritis (RA) is strongly associated with the human leukocyte antigen (HLA) genomic region, most notably with a group of HLA-DRB1 alleles termed the shared epitope (SE). There is also substantial evidence of other risk loci in the HLA region, but refinement has been hampered by extensive linkage disequilibrium (LD). Using genotype imputation, we… (More)
DOI: 10.1111/j.1469-1809.2011.00670.x

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