Using noise to probe and characterize gene circuits.

@article{Cox2008UsingNT,
  title={Using noise to probe and characterize gene circuits.},
  author={Chris D. Cox and James M. McCollum and Michael S. Allen and Roy D. Dar and Michael L. Simpson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 31},
  pages={10809-14}
}
Stochastic fluctuations (or "noise") in the single-cell populations of molecular species are shaped by the structure and biokinetic rates of the underlying gene circuit. The structure of the noise is summarized by its autocorrelation function. In this article, we introduce the noise regulatory vector as a generalized framework for making inferences concerning the structure and biokinetic rates of a gene circuit from its noise autocorrelation function. Although most previous studies have focused… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.

Explore Further: Topics Discussed in This Paper

Citations

Publications citing this paper.
Showing 1-10 of 38 extracted citations

Addressing biological uncertainties in engineering gene circuits.

Integrative biology : quantitative biosciences from nano to macro • 2016

References

Publications referenced by this paper.
Showing 1-10 of 29 references

Combinatorial promoter design for engineering noisy gene expression.

Proceedings of the National Academy of Sciences of the United States of America • 2007

Deterministic characterization of stochastic genetic circuits.

Proceedings of the National Academy of Sciences of the United States of America • 2007

Quantification of protein half-lives in the budding yeast proteome.

Proceedings of the National Academy of Sciences of the United States of America • 2006

Similar Papers

Loading similar papers…