Using native and syntenically mapped cDNA alignments to improve de novo gene finding

@article{Stanke2008UsingNA,
  title={Using native and syntenically mapped cDNA alignments to improve de novo gene finding},
  author={Mario Stanke and Mark Diekhans and Robert Baertsch and David Haussler},
  journal={Bioinformatics},
  year={2008},
  volume={24 5},
  pages={637-44}
}
MOTIVATION Computational annotation of protein coding genes in genomic DNA is a widely used and essential tool for analyzing newly sequenced genomes. However, current methods suffer from inaccuracy and do poorly with certain types of genes. Including additional sources of evidence of the existence and structure of genes can improve the quality of gene predictions. For many eukaryotic genomes, expressed sequence tags (ESTs) are available as evidence for genes. Related genomes that have been… CONTINUE READING
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