Using multiple interdependency to separate functional from phylogenetic correlations in protein alignments

@article{Tillier2003UsingMI,
  title={Using multiple interdependency to separate functional from phylogenetic correlations in protein alignments},
  author={Elisabeth R. M. Tillier and Thomas W. H. Lui},
  journal={Bioinformatics},
  year={2003},
  volume={19 6},
  pages={750-5}
}
MOTIVATION Multiple sequence alignments of homologous proteins are useful for inferring their phylogenetic history and to reveal functionally important regions in the proteins. Functional constraints may lead to co-variation of two or more amino acids in the sequence, such that a substitution at one site is accompanied by compensatory substitutions at another site. It is not sufficient to find the statistical correlations between sites in the alignment because these may be the result of several… CONTINUE READING
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