Using mouse models of autism spectrum disorders to study the neurotoxicology of gene-environment interactions.

@article{Schwartzer2013UsingMM,
  title={Using mouse models of autism spectrum disorders to study the neurotoxicology of gene-environment interactions.},
  author={Jared J. Schwartzer and Claire M. Koenig and Robert F. Berman},
  journal={Neurotoxicology and teratology},
  year={2013},
  volume={36},
  pages={17-35}
}
To better study the role of genetics in autism, mouse models have been developed which mimic the genetics of specific autism spectrum and related disorders. These models have facilitated research on the role genetic susceptibility factors in the pathogenesis of autism in the absence of environmental factors. Inbred mouse strains have been similarly studied to assess the role of environmental agents on neurodevelopment, typically without the complications of genetic heterogeneity of the human… CONTINUE READING
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