Using model substrates to study the dependence of focal adhesion formation on the affinity of integrin-ligand complexes.

@article{Kato2004UsingMS,
  title={Using model substrates to study the dependence of focal adhesion formation on the affinity of integrin-ligand complexes.},
  author={Mihoko Kato and Milan Mrksich},
  journal={Biochemistry},
  year={2004},
  volume={43 10},
  pages={
          2699-707
        }
}
The adhesion of mammalian cells is mediated by the binding of cell-surface integrin receptors to peptide ligands from the extracellular matrix and the clustering of these receptors into focal adhesion complexes. This paper examines the effect of one mechanistic variable, ligand affinity, on the assembly of focal adhesions (FAs) in order to gain mechanistic insight into this process. This study uses self-assembled monolayers of alkanethiolates on gold as a substrate to present either a linear or… CONTINUE READING
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