Using microfluidic platforms to develop CNS-targeted polymeric nanoparticles for HIV therapy.

@article{Martins2018UsingMP,
  title={Using microfluidic platforms to develop CNS-targeted polymeric nanoparticles for HIV therapy.},
  author={Cl{\'a}udia Martins and Francisca Ara{\'u}jo and Maria Jo{\~a}o Gomes and Carlos Fernandes and Rute Nunes and Wei Li and H{\'e}lder A Santos and Fernanda Borges and Bruno Sarmento},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2018},
  volume={138},
  pages={
          111-124
        }
}
The human immunodeficiency virus (HIV) uses the brain as reservoir, which turns it as a promising target to fight this pathology. Nanoparticles (NPs) of poly(lactic-co-glycolic) acid (PLGA) are potential carriers of anti-HIV drugs to the brain, since most of these antiretrovirals, as efavirenz (EFV), cannot surpass the blood-brain barrier (BBB). Forasmuch as the conventional production methods lack precise control over the final properties of particles, microfluidics emerged as a prospective… CONTINUE READING

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