Using metagenomic analyses to estimate the consequences of enrichment bias for pathogen detection

@inproceedings{Pettengill2012UsingMA,
  title={Using metagenomic analyses to estimate the consequences of enrichment bias for pathogen detection},
  author={James B. Pettengill and Eugene McAvoy and James Robert White and Marc William Allard and Eric W. Brown and Andrea R Ottesen},
  booktitle={BMC Research Notes},
  year={2012}
}
Enriching environmental samples to increase the probability of detection has been standard practice throughout the history of microbiology. However, by its very nature, the process of enrichment creates a biased sample that may have unintended consequences for surveillance or resolving a pathogenic outbreak. With the advent of next-generation sequencing and metagenomic approaches, the possibility now exists to quantify enrichment bias at an unprecedented taxonomic breadth. We investigated… CONTINUE READING
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