Using lymph node swelling as a potential biomarker for successful vaccination

@inproceedings{Brewer2016UsingLN,
  title={Using lymph node swelling as a potential biomarker for successful vaccination},
  author={Kimberly D. Brewer and Drew Debay and Iulia Dude and Christa A. Davis and Kerry Lake and Cathryn Parsons and Rajkannan Rajagopalan and Genevieve M Weir and Marianne M Stanford and Marc Mansour and Chris V. Bowen},
  booktitle={Oncotarget},
  year={2016}
}
There is currently a lack of biomarkers to help properly assess novel immunotherapies at both the preclinical and clinical stages of development. Recent work done by our group indicated significant volume changes in the vaccine draining right lymph node (RLN) volumes of mice that had been vaccinated with DepoVaxTM, a lipid-based vaccine platform that was developed to enhance the potency of peptide-based vaccines. These changes in lymph node (LN) volume were unique to vaccinated mice.To better… CONTINUE READING
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