Using in vitro structural alerts for chromosome damage to predict in vivo activity and direct future testing.


While the in vivo genotoxicity of a compound may not always correlate well with its activity in in vitro test systems, for certain compound classes a good overlap may exist between the two endpoints. The difficulty, however, lies in establishing the cases where this relationship holds true and selecting the most appropriate protocol to highlight any… (More)
DOI: 10.1093/mutage/gev047


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