Using in vitro structural alerts for chromosome damage to predict in vivo activity and direct future testing.

Steven J Canipa, Alex Cayley, +5 authors Takeshi Morita
Published 2016 in Mutagenesis

Abstract

While the in vivo genotoxicity of a compound may not always correlate well with its activity in in vitro test systems, for certain compound classes a good overlap may exist between the two endpoints. The difficulty, however, lies in establishing the cases where this relationship holds true and selecting the most appropriate protocol to highlight any… (More)

DOI: 10.1093/mutage/gev047

National Toxicology Program . Bone Marrow Micronucleus
http://tools. niehs.nih.gov/cebs3/ntpViews…
2015

P. N. Judson, S. A. Stalford, J. Vessey
Toxicol. Res.,
2013

Using in vitro structural alerts for chromosome damage to predict in vivo activity and direct future testing.

Abstract

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References

Independent evolution of four heme peroxidase superfamilies

Study Summary of 2-amino-4-nitrophenol, Study ID A12647

Assessing confidence in predictions made by knowledge-based systems

Evaluation of a liver micronucleus assay in young rats (IV): a study using a double-dosing/single-sampling method by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Japanese Environmental Mutagen Society (JEMS)-Mammalian Mutagenicity Study Group (MMS).

Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens III. Appropriate follow-up testing in vivo.

How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop.

Relevance and follow-up of positive results in in vitro genetic toxicity assays: an ILSI-HESI initiative.

Oral chromium(VI) does not affect the frequency of micronuclei in hematopoietic cells of adult mice and of transplacentally exposed fetuses.

Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens I. Sensitivity, specificity and relative predictivity.

Using Argumentation for Absolute Reasoning about the Potential Toxicity of Chemicals

Slides referencing similar topics

Using in vitro structural alerts for chromosome damage to predict in vivo activity and direct future testing.

Abstract

Topics

2 Figures and Tables

Cited By

References

Independent evolution of four heme peroxidase superfamilies

Study Summary of 2-amino-4-nitrophenol, Study ID A12647

Assessing confidence in predictions made by knowledge-based systems

Evaluation of a liver micronucleus assay in young rats (IV): a study using a double-dosing/single-sampling method by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Japanese Environmental Mutagen Society (JEMS)-Mammalian Mutagenicity Study Group (MMS).

Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens III. Appropriate follow-up testing in vivo.

How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop.

Relevance and follow-up of positive results in in vitro genetic toxicity assays: an ILSI-HESI initiative.

Oral chromium(VI) does not affect the frequency of micronuclei in hematopoietic cells of adult mice and of transplacentally exposed fetuses.

Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens I. Sensitivity, specificity and relative predictivity.

Using Argumentation for Absolute Reasoning about the Potential Toxicity of Chemicals

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