UNLABELLED The acute care setting requires a unique skill set for all health care providers, including Doctor of Physical Therapy (DPT) students. This study explores high-fidelity human simulation (HFHS) training in a DPT education program to achieve learning objectives specific to preparation of DPT students for acute care clinical practice. METHODS Twenty-three DPT students participated in a HFHS acute care experience, provided feedback about the learning experience, and completed a survey regarding preparedness for clinical practice. Student feedback was interpreted to gain content validity of the learning experience, and descriptive statistics were used to analyze survey results. RESULTS In this pilot study, students identified four learning objectives met during the simulation experience: interprofessional communication, preparation of the treatment environment, patient safety, and discharge planning. Following the experience, 91.5% of the students reported more confidence in interprofessional communication, and 67% were more knowledgeable in discharge disposition. All students agreed that simulations should be part of the curriculum, and 95.2% reported simulation valuable in preparation for clinical practice. CONCLUSIONS As a result of HFHS training in the DPT program, students' educational objectives were met, and simulation was deemed valuable in integrating prior learning and providing an enhanced understanding of the acute care setting. The findings support continued investigation of the effectiveness of simulation to prepare DPT students for acute care clinical practice.