Using genome-wide measures of coancestry to maintain diversity and fitness in endangered and domestic pig populations.

@article{Bosse2015UsingGM,
  title={Using genome-wide measures of coancestry to maintain diversity and fitness in endangered and domestic pig populations.},
  author={Mirte Bosse and Hendrik-Jan Megens and Ole Hedegaard Madsen and Richard P.M.A. Crooijmans and Oliver A Ryder and Frederic Austerlitz and Martien A M Groenen and M A R de Cara},
  journal={Genome research},
  year={2015},
  volume={25 7},
  pages={
          970-81
        }
}
Conservation and breeding programs aim at maintaining the most diversity, thereby avoiding deleterious effects of inbreeding while maintaining enough variation from which traits of interest can be selected. Theoretically, the most diversity is maintained using optimal contributions based on many markers to calculate coancestries, but this can decrease fitness by maintaining linked deleterious variants. The heterogeneous patterns of coancestry displayed in pigs make them an excellent model to… CONTINUE READING
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