Using genome-wide association studies to identify genes important in serious adverse drug reactions.

@article{Daly2012UsingGA,
  title={Using genome-wide association studies to identify genes important in serious adverse drug reactions.},
  author={Ann K Daly},
  journal={Annual review of pharmacology and toxicology},
  year={2012},
  volume={52},
  pages={21-35}
}
Genome-wide association (GWA) studies have detected novel associations for serious, idiosyncratic, adverse drug reactions including liver toxicity, hypersensitivity, skin rash, and myotoxicity. Human leukocyte antigen (HLA) genotype has been established as an important predictor of susceptibility to drug-induced liver injury, including injury with some drugs where immune-related toxicity was not suspected previously. Similarly, GWA studies have shown a key role for HLA genotype in… CONTINUE READING
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