Using genetic evidence to evaluate four palaeoanthropological hypotheses for the timing of Neanderthal and modern human origins.

@article{Endicott2010UsingGE,
  title={Using genetic evidence to evaluate four palaeoanthropological hypotheses for the timing of Neanderthal and modern human origins.},
  author={Phillip Endicott and Simon Y. W. Ho and Chris B Stringer},
  journal={Journal of human evolution},
  year={2010},
  volume={59 1},
  pages={
          87-95
        }
}
A better understanding of the evolutionary relationship between modern humans and Neanderthals is essential for improving the resolution of hominin phylogenetic hypotheses. [...] Key Method We analysed five dated Neanderthal mitochondrial genomes, together with those of 54 modern humans, and inferred a genetic chronology using multiple age calibrations. Our mean date estimates are consistent with a process of genetic divergence within an ancestral population, commencing approximately 410-440 ka. These results…Expand
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References

SHOWING 1-10 OF 113 REFERENCES
Molecular analysis of Neanderthal DNA from the northern Caucasus
TLDR
Phylogenetic analysis places the two Neanderthals from the Caucasus and western Germany together in a clade that is distinct from modern humans, suggesting that their mtDNA types have not contributed to the modern human mtDNA pool. Expand
The origin of Neandertals
  • J. Hublin
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 2009
TLDR
The term “Homo rhodesiensis” is proposed to be used to designate the large-brained hominins ancestral to H. sapiens in Africa and at the root of the Neandertals in Europe, and the term ‘Homo neanderthalensis’ to designate all of the specimens carrying derived metrical or non-metrical features used in the definition of the LP NeandERTals. Expand
Dental evidence on the hominin dispersals during the Pleistocene
TLDR
The results show important morphological differences between the hominins found in both continents during the Pleistocene, suggesting that their evolutionary courses were relatively independent. Expand
Close correspondence between quantitative- and molecular-genetic divergence times for Neandertals and modern humans
TLDR
A divergence time estimator for neutrally evolving morphological measurements is presented, suggesting that both datasets largely reflect neutral divergence, causing them to track population history or phylogeny rather than the action of diversifying natural selection. Expand
Homo in the middle pleistocene: Hypodigms, variation, and species recognition
TLDR
In this essay, the evidence available from Middle Pleistocene localities in Africa and Europe is emphasized, exploring variation among individuals, composition of hypodigms, species‐level taxonomy, and evolutionary relationships of the hominin populations. Expand
Neandertal evolutionary genetics: mitochondrial DNA data from the iberian peninsula.
TLDR
An estimate of effective population size indicates that the genetic history of the Neandertals was not shaped by an extreme population bottleneck associated with the glacial maximum of 130,000 years ago and fits chronologically with a proposed speciation event of Homo neanderthalensis. Expand
A critical review of the German Paleolithic hominin record.
TLDR
A correlation of AMH with the Aurignacian remains to be proven is proven, and the general idea of a long coexistence of Neandertals and AMH in Europe may be questioned. Expand
When did Neanderthals and modern humans diverge?
TLDR
An estimate and approximate confidence intervals of the population divergence time of Neanderthals and modern humans, using coalescence theory for single-locus data are provided. Expand
Possible Ancestral Structure in Human Populations
TLDR
Using sequence data from the Environmental Genome Project, strong evidence is found for ancient admixture in both a European and a West African population, with contributions to the modern gene pool of at least 5%. Expand
Neanderthal taxonomy reconsidered: implications of 3D primate models of intra- and interspecific differences.
TLDR
The hypothesis that Neanderthals represent a subspecies of H. sapiens is tested by comparing the degree of their morphological differentiation from modern humans to that found within and between 12 species of extant primates. Expand
...
1
2
3
4
5
...