Using genetic and clinical factors to predict tacrolimus dose in renal transplant recipients.

@article{Wang2010UsingGA,
  title={Using genetic and clinical factors to predict tacrolimus dose in renal transplant recipients.},
  author={Ping Wang and Yong Mao and Juan Razo and Xiaobo Zhou and Stephen T. C. Wong and Samir Patel and Erin N Elliott and Erin V. Shea and Alan H. B. Wu and A Osama Gaber},
  journal={Pharmacogenomics},
  year={2010},
  volume={11 10},
  pages={1389-402}
}
AIMS Tacrolimus has a narrow therapeutic window and shows significant interindividual difference in dose requirement. In this study we aim to first identify genetic factors that impact tacrolimus dose using a candidate gene association approach, and then generate a personalized algorithm combining identified genetic and clinical factors to predict individualized tacrolimus dose. MATERIALS & METHODS We screened 768 SNPs in 15 candidate genes in metabolism, transport and calcineurin inhibition… CONTINUE READING

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