Using gene-history and expression analyses to assess the involvement of LGI genes in human disorders.

@article{Gu2005UsingGA,
  title={Using gene-history and expression analyses to assess the involvement of LGI genes in human disorders.},
  author={Wenli Gu and Yann Gibert and Thierry Wirth and Andrea Elischer and Wilhelm Bloch and Axel Meyer and Ortrud K Steinlein and Gerrit Begemann},
  journal={Molecular biology and evolution},
  year={2005},
  volume={22 11},
  pages={2209-16}
}
Mutations in the leucine-rich, glioma-inactivated 1 gene, LGI1, cause autosomal-dominant lateral temporal lobe epilepsy via unknown mechanisms. LGI1 belongs to a subfamily of leucine-rich repeat genes comprising four members (LGI1-LGI4) in mammals. In this study, both comparative developmental as well as molecular evolutionary methods were applied to investigate the evolution of the LGI gene family and, subsequently, of the functional importance of its different gene members. Our phylogenetic… CONTINUE READING
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