Using family history information to distinguish true and false positive model-free linkage results.

@article{Olson1998UsingFH,
  title={Using family history information to distinguish true and false positive model-free linkage results.},
  author={Jane M. Olson and Robert C. Elston},
  journal={Genetic epidemiology},
  year={1998},
  volume={15 2},
  pages={183-92}
}
Genome scans that test for increased marker identity-by-descent sharing between pairs of affected siblings have become increasingly common. These methods do not specify a priori a genetic model for the disease locus and as such lose the ability to specify the parental source of the disease allele. We propose a method that uses family history information to build a more complete model of disease and marker inheritance, while still avoiding specification of the parameters of the disease model of… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.

Similar Papers

Loading similar papers…