Using expression data for quantification of active processes in physiologically based pharmacokinetic modeling.

@article{Meyer2012UsingED,
  title={Using expression data for quantification of active processes in physiologically based pharmacokinetic modeling.},
  author={Michaela Meyer and Sebastian Schneckener and Bernd Ludewig and Lars Kuepfer and J{\"o}rg Lippert},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2012},
  volume={40 5},
  pages={892-901}
}
Active processes involved in drug metabolization and distribution mediated by enzymes, transporters, or binding partners mostly occur simultaneously in various organs. However, a quantitative description of active processes is difficult because of limited experimental accessibility of tissue-specific protein activity in vivo. In this work, we present a novel approach to estimate in vivo activity of such enzymes or transporters that have an influence on drug pharmacokinetics. Tissue-specific… CONTINUE READING