Using epigenome-wide association scans of DNA methylation in age-related complex human traits.

@article{Tsai2012UsingEA,
  title={Using epigenome-wide association scans of DNA methylation in age-related complex human traits.},
  author={Pei-Chien Tsai and Tim D. Spector and Jordana T. Bell},
  journal={Epigenomics},
  year={2012},
  volume={4 5},
  pages={
          511-26
        }
}
With rapid technological advancements emerging epigenetic studies of complex traits have shifted from candidate gene analyses towards epigenome-wide association studies (EWAS). EWAS aim to systematically identify epigenetic variants across the genome that associate with complex phenotypes. Recent EWAS using case-control and disease-discordant identical twin designs have identified phenotype-associated differentially methylated regions for several traits. However, EWAS still face many challenges… 
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