Using empirical Bayes methods in biopharmaceutical research.

@article{Louis1991UsingEB,
  title={Using empirical Bayes methods in biopharmaceutical research.},
  author={Thomas A. Louis},
  journal={Statistics in medicine},
  year={1991},
  volume={10 6},
  pages={811-27; discussion 828-9}
}
A compound sampling model, where a unit-specific parameter is sampled from a prior distribution and then observed are generated by a sampling distribution depending on the parameter, underlies a wide variety of biopharmaceutical data. For example, in a multi-centre clinical trial the true treatment effect varies from centre to centre. Observed treatment effects deviate from these true effects through sampling variation. Knowledge of the prior distribution allows use of Bayesian analysis to… CONTINUE READING

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