Using double-stranded RNA for the control of Laem-Singh Virus (LSNV) in Thai P. monodon.

@article{Saksmerprome2013UsingDR,
  title={Using double-stranded RNA for the control of Laem-Singh Virus (LSNV) in Thai P. monodon.},
  author={Vanvimon Saksmerprome and Thitiporn Thammasorn and Sarocha Jitrakorn and Somjai Wongtripop and Suparerk Borwornpinyo and Boonsirm Withyachumnarnkul},
  journal={Journal of biotechnology},
  year={2013},
  volume={164 4},
  pages={
          449-53
        }
}
Viral inhibition by double-stranded (ds)RNA is a potential therapeutic approach for controlling shrimp viral diseases. Here, we describe the successful oral application of dsRNA targeting Laem-Singh Virus (LSNV) to diminish monodon slow growth syndrome (MSGS) in Thai Penaeus monodon. Shrimp feed formulated with bacterially expressed LSNV-dsRNA was given to shrimp for 9 weeks. RT-PCR results revealed that all control shrimp were LSNV-positive at the end of experiment, while the shrimp that… CONTINUE READING
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