Using dietary exposure and physiologically based pharmacokinetic/pharmacodynamic modeling in human risk extrapolations for acrylamide toxicity.

@article{Doerge2008UsingDE,
  title={Using dietary exposure and physiologically based pharmacokinetic/pharmacodynamic modeling in human risk extrapolations for acrylamide toxicity.},
  author={Daniel R. Doerge and John Fariselli Young and James J. Chen and Michael J Dinovi and Sara H. Henry},
  journal={Journal of agricultural and food chemistry},
  year={2008},
  volume={56 15},
  pages={6031-8}
}
The discovery of acrylamide (AA) in many common cooked starchy foods has presented significant challenges to toxicologists, food scientists, and national regulatory and public health organizations because of the potential for producing neurotoxicity and cancer. This paper reviews some of the underlying experimental bases for AA toxicity and earlier risk assessments. Then, dietary exposure modeling is used to estimate probable AA intake in the U.S. population, and physiologically based… CONTINUE READING