Using cure models and multiple imputation to utilize recurrence as an auxiliary variable for overall survival.

@article{Conlon2011UsingCM,
  title={Using cure models and multiple imputation to utilize recurrence as an auxiliary variable for overall survival.},
  author={Anna Conlon and Jeremy M. G. Taylor and Daniel J. Sargent and Greg Yothers},
  journal={Clinical trials},
  year={2011},
  volume={8 5},
  pages={581-90}
}
BACKGROUND Intermediate outcome variables can often be used as auxiliary variables for the true outcome of interest in randomized clinical trials. For many cancers, time to recurrence is an informative marker in predicting a patient's overall survival outcome and could provide auxiliary information for the analysis of survival times. PURPOSE To investigate whether models linking recurrence and death combined with a multiple imputation procedure for censored observations can result in… CONTINUE READING