Using computational method to identify the binding site of 8R-lipoxygenase for arachidonic acid

Abstract

Lipoxygenases (LOX) play important roles in the biosynthesis of biologically active eicosanoids form polyunsaturated fatty acids. An understanding of the structure basis of LOX familiy is critical for the development of LOX specific inhibitors. In this study, a computational method, Internal Coordinate Mechanics (ICM) was applied to find the binding site of… (More)

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