Using chemical approaches to study selenoproteins-focus on thioredoxin reductases.

@article{Hondal2009UsingCA,
  title={Using chemical approaches to study selenoproteins-focus on thioredoxin reductases.},
  author={Robert J Hondal},
  journal={Biochimica et biophysica acta},
  year={2009},
  volume={1790 11},
  pages={
          1501-12
        }
}
The study of selenocysteine-containing proteins is difficult due to the problems associated with the heterologous production of these proteins. These problems are due to the intricate recoding mechanism used by cells to translate the UGA codon as a sense codon for selenocysteine. The process is further complicated by the fact that eukaryotes and prokaryotes have different UGA recoding machineries. This review focuses on chemical approaches to produce selenoproteins and study the mechanism of… CONTINUE READING
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