Using changes in hydrostatic and osmotic pressure to manipulate metabolic function in chondrocytes.

@article{Mizuno2011UsingCI,
  title={Using changes in hydrostatic and osmotic pressure to manipulate metabolic function in chondrocytes.},
  author={Shuichi Mizuno and Rei Ogawa},
  journal={American journal of physiology. Cell physiology},
  year={2011},
  volume={300 6},
  pages={C1234-45}
}
Articular cartilage has distinct histological depth zones. In each zone, chondrocytes are subject to different hydrostatic (HP) and osmotic pressure (OP) due to weight-bearing and joint-loading. Previous in vitro studies of regeneration and pathophysiology in cartilage have failed to consider the characteristics of histological heterogeneity and the effects of combinations of changes in HP and OP. Thus, we have constructed molecular, biochemical, and histological profiles of anabolic and… CONTINUE READING

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