Using cell engineering and omic tools for the improvement of cell culture processes

@article{Kuystermans2007UsingCE,
  title={Using cell engineering and omic tools for the improvement of cell culture processes},
  author={Darrin Kuystermans and Britta Krampe and Halina Swiderek and Mohamed Al-Rubeai},
  journal={Cytotechnology},
  year={2007},
  volume={53},
  pages={3-22}
}
Significant strides have been made in mammalian cell based biopharmaceutical process and cell line development over the past years. With several established mammalian host cell lines and expression systems, optimization of selection systems to reduce development times and improvement of glycosylation patterns are only some of the advances being made to improve cell culture processes. In this article, the advances pertaining to cell line development and cell engineering strategies are discussed… CONTINUE READING

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