Using aptamers to identify and enter cells.


While nucleic acid binding species (aptamers) have previously been selected against a variety of biomedically important protein targets, the selection of aptamers against complex targets, such as cell surfaces and organisms, is becoming increasingly feasible. A number of aptamers have now been generated that can target specific cell-surface antigens and cell types, including tumor biomarkers and tumor cells. The generation of anti-cell aptamers has important implications for identifying disease-specific biomarkers, generating diagnostics, and developing novel drug delivery strategies.

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@article{Chu2007UsingAT, title={Using aptamers to identify and enter cells.}, author={Ted Chu and Jessica N. Ebright and Andrew D. Ellington}, journal={Current opinion in molecular therapeutics}, year={2007}, volume={9 2}, pages={137-44} }