Using an ancient tool for igniting and propagating immune tolerance: IDO as an inducer and amplifier of regulatory T cell functions.

@article{Fallarino2011UsingAA,
  title={Using an ancient tool for igniting and propagating immune tolerance: IDO as an inducer and amplifier of regulatory T cell functions.},
  author={Francesca Fallarino and Ursula Grohmann},
  journal={Current medicinal chemistry},
  year={2011},
  volume={18 15},
  pages={
          2215-21
        }
}
Although most CD4(+)CD25(+) regulatory T (T(reg)) cells develop in the thymus (i.e., natural T(reg) or nT(reg)), accumulating evidence suggests that they can also develop in the periphery (adaptive/induced T(reg) or iT(reg)). Both types of cells are functionally associated with the expression of Foxp3, a transcription factor that is constitutively expressed in nT(reg) cells and inducible during iT(reg) cell generation from CD4+CD25- T lymphocytes. Multiple factors are involved in the generation… CONTINUE READING

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