Using a large-scale knowledge database on reactions and regulations to propose key upstream regulators of various sets of molecules participating in cell metabolism

@inproceedings{Blavy2013UsingAL,
  title={Using a large-scale knowledge database on reactions and regulations to propose key upstream regulators of various sets of molecules participating in cell metabolism},
  author={Pierre Blavy and Florence Gondret and Sandrine Lagarrigue and Jaap Van Milgen and Anne Siegel},
  booktitle={BMC Systems Biology},
  year={2013}
}
Most of the existing methods to analyze high-throughput data are based on gene ontology principles, providing information on the main functions and biological processes. However, these methods do not indicate the regulations behind the biological pathways. A critical point in this context is the extraction of information from many possible relationships between the regulated genes, and its combination with biochemical regulations. This study aimed at developing an automatic method to propose a… CONTINUE READING