Using Stochastic Differential Equations for PK/PD Model Development

  title={Using Stochastic Differential Equations for PK/PD Model Development},
  author={Niels Rode Kristensen and Henrik Madsen and Steen Hvass Ingwersen},
  journal={Journal of Pharmacokinetics and Pharmacodynamics},
A method for PK/PD model development based on stochastic differential equation models is proposed. The new method has a number of advantages compared to conventional methods. In particular, the new method avoids the exhaustive trial-and-error based search often conducted to determine the most appropriate model structure, because it allows information about the appropriate model structure to be extracted directly from data. This is accomplished through quantification of the uncertainty of the… CONTINUE READING


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