Using State Variables to Model the Response of Tumour Cells to Radiation and Heat: A Novel Multi-Hit-Repair Approach

@inproceedings{Scheidegger2013UsingSV,
  title={Using State Variables to Model the Response of Tumour Cells to Radiation and Heat: A Novel Multi-Hit-Repair Approach},
  author={Stephan Scheidegger and Hans U. Fuchs and Kathrin Zaugg and Stephan Bodis and Rudolf M. F{\"u}chslin},
  booktitle={Comp. Math. Methods in Medicine},
  year={2013}
}
In order to overcome the limitations of the linear-quadratic model and include synergistic effects of heat and radiation, a novel radiobiological model is proposed. The model is based on a chain of cell populations which are characterized by the number of radiation induced damages (hits). Cells can shift downward along the chain by collecting hits and upward by a repair process. The repair process is governed by a repair probability which depends upon state variables used for a simplistic… CONTINUE READING

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