Using Serum Creatinine To Estimate Glomerular Filtration Rate: Accuracy in Good Health and in Chronic Kidney Disease

@article{Rule2004UsingSC,
  title={Using Serum Creatinine To Estimate Glomerular Filtration Rate: Accuracy in Good Health and in Chronic Kidney Disease},
  author={A. Rule and T. Larson and E. Bergstralh and J. Slezak and S. Jacobsen and F. Cosio},
  journal={Annals of Internal Medicine},
  year={2004},
  volume={141},
  pages={929-937}
}
  • A. Rule, T. Larson, +3 authors F. Cosio
  • Published 2004
  • Medicine
  • Annals of Internal Medicine
  • Context Experts increasingly use the Modification of Diet in Renal Disease (MDRD) equation to estimate glomerular filtration rate (GFR). Contribution This cross-sectional study compared GFR estimated by the MDRD equation with GFR measured by iothalamate clearance in 320 patients with chronic kidney disease and 580 healthy kidney donor candidates. The MDRD equation underestimated GFR by 6% in patients with kidney disease and by 29% in healthy persons. The authors also derived a quadratic… CONTINUE READING

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