Using SHIVs to develop an anti-HIV-1 live-attenuated vaccine.

@article{Kuwata2001UsingST,
  title={Using SHIVs to develop an anti-HIV-1 live-attenuated vaccine.},
  author={Takeo Kuwata and Tomoyuki Miura and Masanori Hayami},
  journal={Trends in microbiology},
  year={2001},
  volume={9 10},
  pages={475-80}
}
The use of chimeric simian and human immunodeficiency viruses (SHIVs) that encode HIV-1 Env and are infectious to macaques has made it possible to analyze the pathogenicity of HIV-1 in vivo, and to evaluate the efficacy of candidate vaccines in macaques. In addition, we believe that gene-deleted SHIVs could potentially be used as anti-HIV-1 live-attenuated… CONTINUE READING