Using S. cerevisiae as a Model System to Investigate V. cholerae VopX-Host Cell Protein Interactions and Phenotypes

@article{Seward2015UsingSC,
  title={Using S. cerevisiae as a Model System to Investigate V. cholerae VopX-Host Cell Protein Interactions and Phenotypes},
  author={C. Seward and Alexander Manzella and A. Alam and J. Butler and M. Dziejman},
  journal={Toxins},
  year={2015},
  volume={7},
  pages={4099 - 4110}
}
  • C. Seward, Alexander Manzella, +2 authors M. Dziejman
  • Published 2015
  • Biology, Medicine
  • Toxins
  • Most pathogenic, non-O1/non-O139 serogroup Vibrio cholerae strains cause diarrheal disease in the absence of cholera toxin. Instead, many use Type 3 Secretion System (T3SS) mediated mechanisms to disrupt host cell homeostasis. We identified a T3SS effector protein, VopX, which is translocated into mammalian cells during in vitro co-culture. In a S. cerevisiae model system, we found that expression of VopX resulted in a severe growth defect that was partially suppressed by a deletion of RLM1… CONTINUE READING
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