Using Ribosomal Protein Genes as Reference: A Tale of Caution

  title={Using Ribosomal Protein Genes as Reference: A Tale of Caution},
  author={Lieven Thorrez and Katrijn Van Deun and L{\'e}on-Charles Tranchevent and Leentje van Lommel and Kristof Engelen and Kathleen Marchal and Yves Moreau and Iven van Mechelen and Frans Schuit},
  journal={PLoS ONE},
  pages={95 - 96}
BACKGROUND Housekeeping genes are needed in every tissue as their expression is required for survival, integrity or duplication of every cell. Housekeeping genes commonly have been used as reference genes to normalize gene expression data, the underlying assumption being that they are expressed in every cell type at approximately the same level. Often, the terms "reference genes" and "housekeeping genes" are used interchangeably. In this paper, we would like to distinguish between these terms… CONTINUE READING
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