Using Plasma Viral Load to Guide Antiretroviral Therapy Initiation to Prevent HIV-1 Transmission

@inproceedings{Murnane2012UsingPV,
  title={Using Plasma Viral Load to Guide Antiretroviral Therapy Initiation to Prevent HIV-1 Transmission},
  author={Pamela M. Murnane and James P. Hughes and Connie L Celum and Jairam R Lingappa and Nelly R. Mugo and Carey Farquhar and James N Kiarie and Anna Wald and Jared M Baeten},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Current WHO guidelines recommend antiretroviral therapy (ART) initiation at CD4 counts ≤350 cells/µL. Increasing this threshold has been proposed, with a primary goal of reducing HIV-1 infectiousness. Because the quantity of HIV-1 in plasma is the primary predictor of HIV-1 transmission, consideration of plasma viral load in ART initiation guidelines is warranted. METHODS Using per-sex-act infectivity estimates and cross-sectional sexual behavior data from 2,484 HIV-1 infected… CONTINUE READING