Using Molecular Tweezers to Remodel Abnormal Protein Self-Assembly and Inhibit the Toxicity of Amyloidogenic Proteins.

@article{Malik2018UsingMT,
  title={Using Molecular Tweezers to Remodel Abnormal Protein Self-Assembly and Inhibit the Toxicity of Amyloidogenic Proteins.},
  author={Ravinder Paul Singh Malik and Jing Di and G. Udayabhanu Nair and Aida El Attar and Karen Davinia Taylor and Edmond Teng and F. G. Kl{\"a}rner and Thomas Schrader and Gal Bitan},
  journal={Methods in molecular biology},
  year={2018},
  volume={1777},
  pages={
          369-386
        }
}
Molecular tweezers (MTs) are broad-spectrum inhibitors of abnormal protein self-assembly, which act by binding selectively to lysine and arginine residues. Through this unique mechanism of action, MTs inhibit formation of toxic oligomers and aggregates. Their efficacy and safety have been demonstrated in vitro, in cell culture, and in animal models. Here, we discuss the application of MTs in diverse in vitro and in vivo systems, the experimental details, the scope of their use, and the… CONTINUE READING
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