Using HapMap tools in pharmacogenomic discovery: the thiopurine methyltransferase polymorphism.

@article{Jones2007UsingHT,
  title={Using HapMap tools in pharmacogenomic discovery: the thiopurine methyltransferase polymorphism.},
  author={Terreia S. Jones and William Yang and W E Evans and M V Relling},
  journal={Clinical pharmacology and therapeutics},
  year={2007},
  volume={81 5},
  pages={729-34}
}
One purpose of the International HapMap Project is to provide a genome-wide resource to discover pharmacogenetic determinants of drug response. The thiopurine methyltransferase (TPMT) 719A>G single-nucleotide polymorphism (SNP) causes decreased TPMT activity, increased intracellular thiopurines, and drug toxicities. Using HapMap cell lines and 3.3 million… CONTINUE READING