Using Galaxy-P to leverage RNA-Seq for the discovery of novel protein variations

  title={Using Galaxy-P to leverage RNA-Seq for the discovery of novel protein variations},
  author={Gloria M. Sheynkman and James E. Johnson and Pratik D Jagtap and Michael R. Shortreed and Getiria Onsongo and Brian L Frey and Timothy J. Griffin and Lloyd M. Smith},
  booktitle={BMC Genomics},
Current practice in mass spectrometry (MS)-based proteomics is to identify peptides by comparison of experimental mass spectra with theoretical mass spectra derived from a reference protein database; however, this strategy necessarily fails to detect peptide and protein sequences that are absent from the database. We and others have recently shown that customized proteomic databases derived from RNA-Seq data can be employed for MS-searching to both improve MS analysis and identify novel… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 13 times over the past 90 days. VIEW TWEETS
22 Citations
39 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 22 extracted citations


Publications referenced by this paper.
Showing 1-10 of 39 references

A program for annotating and predicting the effects of single nucleotide polymorphisms , SnpEff : SNPs in the genome of drosophila melanogaster strain w 1118 ; iso - 2 ; iso - 3

  • P Cingolani, A Platts, +6 authors DM Ruden
  • Fly ( Austin )
  • 2012

Similar Papers

Loading similar papers…