Using Flp-recombinase to characterize expansion of Wnt1-expressing neural progenitors in the mouse.

@article{Dymecki1998UsingFT,
  title={Using Flp-recombinase to characterize expansion of Wnt1-expressing neural progenitors in the mouse.},
  author={Susan M Dymecki and Henry Tomasiewicz},
  journal={Developmental biology},
  year={1998},
  volume={201 1},
  pages={57-65}
}
Here we demonstrate how a Flp recombinase-based tagging system can be used to link temporally distinct developmental events in the mouse. By directly following Flp-mediated DNA rearrangements we have analyzed the adult expansion of embryonic neural progenitors which transiently express the signaling factor Wnt1. We report Wnt1 promoter activity in embryonic cells that give rise to aspects of the adult midbrain, cerebellum, spinal cord, and dorsal root ganglia. These findings show that cells… CONTINUE READING