Using Flory-Huggins phase diagrams as a pre-formulation tool for the production of amorphous solid dispersions: a comparison between hot-melt extrusion and spray drying.

@article{Tian2014UsingFP,
  title={Using Flory-Huggins phase diagrams as a pre-formulation tool for the production of amorphous solid dispersions: a comparison between hot-melt extrusion and spray drying.},
  author={Yiwei Tian and Vincent Caron and D. S. Jones and A. M. Healy and Gavin P Andrews},
  journal={The Journal of pharmacy and pharmacology},
  year={2014},
  volume={66 2},
  pages={256-74}
}
OBJECTIVES Amorphous drug forms provide a useful method of enhancing the dissolution performance of poorly water-soluble drugs; however, they are inherently unstable. In this article, we have used Flory-Huggins theory to predict drug solubility and miscibility in polymer candidates, and used this information to compare spray drying and melt extrusion as processes to manufacture solid dispersions. METHOD Solid dispersions were prepared using two different techniques (hot-melt extrusion and… CONTINUE READING