Using Family-Based Imputation in Genome-Wide Association Studies with Large Complex Pedigrees: The Framingham Heart Study

@inproceedings{Chen2012UsingFI,
  title={Using Family-Based Imputation in Genome-Wide Association Studies with Large Complex Pedigrees: The Framingham Heart Study},
  author={M C Chen and Jie Tang Yan Huang and Wei-Min Chen and Martin G. Larson and Caroline Fox and Ramachandran S. Vasan and Sudha Seshadri and Christopher J. O’Donnell and Qiong Yang},
  booktitle={PloS one},
  year={2012}
}
Imputation has been widely used in genome-wide association studies (GWAS) to infer genotypes of un-genotyped variants based on the linkage disequilibrium in external reference panels such as the HapMap and 1000 Genomes. However, imputation has only rarely been performed based on family relationships to infer genotypes of un-genotyped individuals. Using 8998 Framingham Heart Study (FHS) participants genotyped with Affymetrix 550K SNPs, we imputed genotypes of same set of SNPs for additional 3121… CONTINUE READING
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