Using CSF biomarkers to replicate genetic associations in Alzheimer's disease.

@article{Schott2012UsingCB,
  title={Using CSF biomarkers to replicate genetic associations in Alzheimer's disease.},
  author={Jonathan M. Schott},
  journal={Neurobiology of aging},
  year={2012},
  volume={33 7},
  pages={1486.e9-15}
}
Defining cases and controls on the basis of biomarkers rather than clinical diagnosis may reduce sample sizes required for genetic studies. The aim of this study was to assess whether characterizing case/control status on the basis of cerebrospinal fluid (CSF) profile would increase power to replicate known genetic associations for Alzheimer's disease (AD). Independent of clinical diagnosis, Alzheimer's Disease Neuroimaging Initiative (ADNI) subjects with 2 CSF biomarkers for AD (Aβ1-42 < 192… CONTINUE READING
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