Using Alu elements as polyadenylation sites: A case of retroposon exaptation.

  title={Using Alu elements as polyadenylation sites: A case of retroposon exaptation.},
  author={Chongjian Chen and Takeshi Ara and Daniel Gautheret},
  journal={Molecular biology and evolution},
  volume={26 2},
Of the 1.1 million Alu retroposons in the human genome, about 10,000 are inserted in the 3' untranslated regions (UTR) of protein-coding genes and 1% of these (107 events) are active as polyadenylation sites (PASs). Strikingly, although Alu's in 3' UTR are indifferently inserted in the forward or reverse direction, 99% of polyadenylation-active Alu sequences are forward oriented. Consensus Alu+ sequences contain sites that can give rise to polyadenylation signals and enhancers through a few… CONTINUE READING
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Phylogenetic analysis of mRNA polyadenylation sites reveals a role of transposable elements in evolution of the 3 #end of genes

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