Uses the ATM Signaling Pathway to Induce p 53 and Chk 2 Phosphorylation and Apoptosis

@inproceedings{Powers2004UsesTA,
  title={Uses the ATM Signaling Pathway to Induce p 53 and Chk 2 Phosphorylation and Apoptosis},
  author={John T. Powers and Sungki Hong and Christopher N. Mayhew and Pamela M. Rogers and Erik S. Knudsen and D. B. Johnson},
  year={2004}
}
The p53 tumor suppressor protein is phosphorylated and activated by several DNA damage-inducible kinases, such as ATM, and is a key effector of the DNA damage response by promoting cell cycle arrest or apoptosis. Deregulation of the Rb-E2F1 pathway also results in the activation of p53 and the promotion of apoptosis, and this contributes to the suppression of tumor development. Here, we describe a novel connection between E2F1 and the ATM DNA damage response pathway. In primary human… CONTINUE READING

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References

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Regulation of E2F1 by BRCT domain-containing protein TopBP1.

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