Users' guides to the medical literature: XV. How to use an article about disease probability for differential diagnosis. Evidence-Based Medicine Working Group.

@article{Richardson1999UsersGT,
  title={Users' guides to the medical literature: XV. How to use an article about disease probability for differential diagnosis. Evidence-Based Medicine Working Group.},
  author={W. Scott Richardson and M. C. Wilson and Gordon H. Guyatt and Deborah J. Cook and Jim Nishikawa},
  journal={JAMA},
  year={1999},
  volume={281 13},
  pages={
          1214-9
        }
}
CLINICAL SCENARIO You are an experienced clinician working at a hospital emergency department. One morning, a 33-year-old man presents with palpitations. He describes the new onset of episodes of fast, regular chest pounding, which come on gradually, last 1 to 2 minutes, and occur several times a day. He reports no relation of symptoms to activities and no change in exercise tolerance. He is very anxious and tells you he fears heart disease. He has no other symptoms, no personal or family… 

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The patient is a 28-year-old man whose acute onset of shortness of breath and vague chest pain began shortly after completing a 10-hour auto trip, and the physician is very apprehensive about his symptoms.
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A 78-year-old woman, now 10 days after abdominal surgery, who has become increasingly short of breath over the last 24 hours, is seen by a medical consultant asked by a surgical colleague to see her.
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A 76-year-old retired schoolteacher who has lived with her son since her husband died 6 years ago has become increasingly agitated and paranoid during the last year and you feel she has probable Alzheimer's disease.
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