Usefulness of soluble and surface-bound P-selectin in detecting heightened platelet activity in patients with congestive heart failure.

@article{OConnor1999UsefulnessOS,
  title={Usefulness of soluble and surface-bound P-selectin in detecting heightened platelet activity in patients with congestive heart failure.},
  author={Christopher M. O'Connor and Paul A Gurbel and Victor L. Serebruany},
  journal={The American journal of cardiology},
  year={1999},
  volume={83 9},
  pages={
          1345-9
        }
}
P-selectin is an important marker of platelet activation and may be up-regulated in patients with congestive heart failure (CHF). We sought to prospectively compare simultaneously determined platelet and soluble P-selectin in patients with CHF and in healthy controls. Matched soluble levels by enzyme-linked immmunosorbent assay, and platelet-bound expression by whole blood flow cytometry of P-selectin were measured in 22 patients with CHF and compared with 14 healthy controls. Twelve patients… CONTINUE READING

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