Usefulness of granulocyte colony-stimulating factor in patients with a large anterior wall acute myocardial infarction to prevent left ventricular remodeling (the rigenera study).

@article{Leone2007UsefulnessOG,
  title={Usefulness of granulocyte colony-stimulating factor in patients with a large anterior wall acute myocardial infarction to prevent left ventricular remodeling (the rigenera study).},
  author={Antonio Maria Leone and Leonarda Galiuto and Barbara Garramone and Sergio Rutella and Maria Benedetta Giannico and Salvatore Brugaletta and M. Perfetti and Giovanna Liuzzo and Italo Porto and Francesco Burzotta and Giampaolo Niccoli and Luigi Marzio Biasucci and Giuseppe Leone and Antonio Giuseppe Rebuzzi and Filippo Crea},
  journal={The American journal of cardiology},
  year={2007},
  volume={100 3},
  pages={397-403}
}
Intracoronary injection of bone marrow stem cells seems to improve left ventricular (LV) function after acute myocardial infarction (AMI). Granulocyte colony-stimulating factor (G-CSF) could improve myocardial function and perfusion noninvasively through mobilization of stem cells into peripheral blood, although previous clinical trials have produced controversial results. Forty-one patients with large anterior wall AMI at high risk of unfavorable remodeling were randomized 1:2 to G-CSF (10… CONTINUE READING